Pep Guardiola excluded De Bruyne from Manchester City's matchday squad after expressing concern about the Belgian's fitness. De Bruyne was injured during last weekend's League Cup final, and he sat out the midweek FA Cup fixture against Sheffield Wednesday.
Similarly, Maguire was held out of Manchester United's FA Cup match against Derby County with an ankle injury.
City XI: Ederson; Cancelo, Fernandinho, Otamendi, Zinchenko; Gundogan, Rodri, Foden; Bernardo, Aguero, Sterling
United XI: De Gea; Lindelof, Maguire, Shaw; Wan-Bissaka, Fred, Matic, Williams; Fernandes; James, Martial