49ers' Bosa suffers knee injury in win over Cardinals
Kavin Mistry / Getty Images Sport / Getty
San Francisco 49ers edge rusher Nick Bosa suffered a knee injury during Sunday's 16-15 victory over the Arizona Cardinals.
Bosa appeared to injure himself when he was taken to the ground in the first quarter and did not return to the game.
#49ers DE Nick Bosa shaken up after this play on third down. pic.twitter.com/4y2mKrJ3Y1
— Alex Tran (@nineralex) September 21, 2025
He got off the field and immediately went down before he was looked at by the team's training staff. He signaled a "thumbs down" to the crowd.
Nick Bosa signaled a 👎 to someone in the crowd after he was shaken up with a possible injury. pic.twitter.com/82bo7OeDZL
— Alex Tran (@nineralex) September 21, 2025
Bosa entered Sunday with two sacks through two games this season.
The 27-year-old has made five Pro Bowl teams in his seven-year NFL career.