"It feels good to shut them up," Contreras said postgame of the shush signal he directed toward the crowd at American Family Field in Milwaukee, according to Tim Stebbins of NBC Sports Chicago.
"That was a message sent," he added.
Contreras' blast came after a pitch from Brandon Woodruff hit him in the fourth inning, which has become a pattern when the Cubs backstop suits up against the Brewers.
Seven pitches have hit the 28-year-old over his last 14 games played against Milwaukee.
Tempers also flared between the Cubs and Brewers in the fifth inning when right-hander Ryan Tepera threw behind Woodruff, seemingly in response to Contreras being plunked an inning earlier.
Chicago ended up winning the game 3-2. The two teams will meet again on Wednesday.