"Following a specialist's opinion, Paul Pogba requires a period of further rest and conservative treatment for the foot injury he sustained during the game against Southampton in August. Updates will follow in due course," United's statement read.
The midfielder won't travel with United's squad for Thursday's Europa League match at AZ Alkmaar.
Reports earlier in the week suggested Pogba had aggravated an ankle injury suffered versus the Saints during Monday's draw with Arsenal. He missed three matches following the initial injury before playing 90 minutes against both Rochdale and the Gunners.
Pogba is now at risk of missing another international break with France after his ankle worry ruled him out of a pair of Euro 2020 qualifiers against Albania and Andorra in early September.
United's statement also revealed the 21-man squad for Thursday's visit to the Netherlands, with Anthony Martial, Phil Jones, Luke Shaw, and Aaron Wan-Bissaka all absent as they recover from their respective injuries.
The squad is listed as follows:
GK: David De Gea, Sergio Romero, Lee Grant; DF: Diogo Dalot, Victor Lindelof, Harry Maguire, Axel Tuanzebe, Marcos Rojo, Brandon Williams; MF: Scott McTominay, Nemanja Matic, Fred, James Garner, Andreas Pereira, Juan Mata, Jesse Lingard, Angel Gomes, Daniel James; FW: Tahith Chong, Marcus Rashford, Mason Greenwood.