The opponent, date, and time were not revealed. The last three games in Mexico City took place on Monday Night Football, while a fourth contest was also scheduled for a Monday in 2018 before field conditions forced a relocation.
Regular-season NFL games in Mexico
|Year||Home team||Away team|
*Game relocated due to concerns about field conditions
The Cardinals played in Mexico City in 2005 against the San Francisco 49ers - the first NFL regular-season game that was held outside the United States.
"Two years ago, when the NFL awarded Super Bowl LVII to Arizona and State Farm Stadium, we understood the requirement of hosting an international game before 2023," Cardinals chairman Michael Bidwill said in a statement.
"We are thrilled to learn that this game will take place at Estadio Azteca where we received such an enthusiastic reception in 2005. We are extremely grateful for the support we receive from fans in Mexico and look forward to an incredible experience."
In 2020, Arizona will host the 49ers, Buffalo Bills, Detroit Lions, Los Angeles Rams, Miami Dolphins, Philadelphia Eagles, Seattle Seahawks, and Washington Redskins.
The full NFL schedule will be unveiled in April.