Guice met with orthopedic surgeon Dr. James Andrews earlier Thursday to get a second opinion on his torn meniscus, sources told ESPN's Adam Schefter.
Schefter previously reported the running back would be facing a six-to-eight week recovery if he did go under the knife.
Guice's injury is to his right knee. The running back missed all of last season after suffering a torn ACL in his left knee.
Despite his poor injury luck, Guice appeared to be in good spirits when penning a tweet on Thursday.
Redskins head coach Jay Gruden said Wednesday that Adrian Peterson will start in Guice's absence. The likely future Hall of Famer was a healthy scratch for the first time in his 13-year career in Week 1.