Gottlieb, who was aggressively recruited to leave her current post, will have a six-year deal, sources told ESPN's Adrian Wojnarowski.
"After an incredible experience in the NBA, Lindsay is taking leadership of our program at a time when she has become her very best as a coach and teacher, and we have the utmost confidence in her ability to lead the Women of Troy back to national prominence," Trojans athletic director Mike Bohn said in a statement.
Gottlieb was hired to then-Cavs coach John Beilein's staff in 2019 after taking Cal to seven NCAA Tournament appearances as head coach from 2011-19. After Beilein stepped down midway through last season, Gottlieb continued in her role under J.B. Bickerstaff, earning a promotion to the front bench.
The once-mighty Women of Troy have fallen on tough times of late, making just one NCAA Tournament appearance in the past 15 years: a first-round exit in 2014.
The team went 11-12 under Mark Trakh in 2020-21, after which he closed his second stint as USC bench boss by announcing his retirement.