It's the fourth 50-point triple-double of Harden's career, surpassing Russell Westbrook for most in NBA history.
Harden managed to hit the half century mark on 26 shots and hit 18 of 19 free throws.
The reigning MVP remains the lone player with a 60-point triple-double.
It's Harden's second 50-point game of the regular season, raising the league total to nine through two months. He previously scored a season-high 54 points in an overtime loss to the Washington Wizards.