The two-time All-Star has yet to pitch for the Yankees in 2019 due to injuries after becoming a fixture atop the rotation over the previous two seasons.
The 25-year-old Severino was sidelined in spring training with a shoulder injury before an unrelated lat strain further delayed his recovery.
While the Yankees have cruised to the top of the AL East this year, starting pitching has been a concern, as the rotation ranks 17th in the majors with a 4.62 ERA.
Boone is eager to get his ace back into the fold.
"No question we're excited to get him back," Boone said. "I feel like he's been in a pretty good place physically now for a couple of months and building really good momentum. I feel like his progression has gone really smooth.
"He could be a game-changer guy for us, there's no question."
Since the beginning of 2017, Severino has gone 33-14 with a 3.18 ERA, a 1.09 WHIP, and 450 strikeouts in 384 2/3 innings while finishing in the top 10 in Cy Young Award voting in back-to-back seasons.